Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

Small cell lung cancer (SCLC) is an aggressive disease with high mortality, and the identification of effective pharmacological strategies to target SCLC biology represents an urgent need. Using a high-throughput cellular screen of a diverse chemical library, we observe that SCLC is sensitive to tra...

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Main Authors: Christensen, Camilla L (Author), Carretero, Julian (Author), Al-Shahrour, Fatima (Author), Zhang, Tinghu (Author), Chipumuro, Edmond (Author), Herter-Sprie, Grit S (Author), Akbay, Esra A (Author), Altabef, Abigail (Author), Zhang, Jianming (Author), Shimamura, Takeshi (Author), Capelletti, Marzia (Author), Reibel, Jakob B (Author), Cavanaugh, Jillian D (Author), Gao, Peng (Author), Liu, Yan (Author), Michaelsen, Signe R (Author), Poulsen, Hans S (Author), Aref, Amir R (Author), Barbie, David A (Author), Bradner, James E (Author), George, Rani E (Author), Gray, Nathanael S (Author), Wong, Kwok-Kin (Author), Kwiatkowski, Nick (Contributor), Abraham, Brian Joseph (Contributor), Young, Richard A. (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-04-20T18:48:41Z.
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