Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner

Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner

ephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair intermediates that damage healthy tissues. We have...

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Bibliographic Details
Main Authors: Bronson, Roderick T. (Author), Calvo, Jennifer (Contributor), Allocca, Mariacarmela (Contributor), Fake, Kimberly (Contributor), Muthupalani, Sureshkumar (Contributor), Corrigan, Joshua (Contributor), Samson, Leona D (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: Impact Journals/National Center for Biotechnology Information (U.S.), 2017-04-21T17:02:53Z.
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