Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers and shows resistance to any therapeutic strategy used. Here we tested small-molecule inhibitors targeting chromatin regulators as possible therapeutic agents in PDAC. We show that JQ1, an inhibitor of the bromodomain and...

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Main Authors: Mazur, Pawel K. (Author), Herner, Alexander (Author), Mello, Stephano S. (Author), Wirth, Matthias (Author), Hausmann, Simone (Author), Lofgren, Shane M. (Author), Kuschma, Timo (Author), Hahn, Stephan A. (Author), Vangala, Deepak (Author), Trajkovic-Arsic, Marija (Author), Gupta, Aayush (Author), Heid, Irina (Author), Noel, Peter B. (Author), Braren, Rickmer (Author), Erkan, Mert (Author), Kleeff, Jorg (Author), Sipos, Bence (Author), Sayles, Leanne C. (Author), Heikenwalder, Mathias (Author), Hessmann, Elizabeth (Author), Ellenrieder, Volker (Author), Esposito, Irene (Author), Bradner, James E. (Author), Khatri, Purvesh (Author), Sweet-Cordero, E Alejandro (Author), Attardi, Laura D. (Author), Schmid, Roland M. (Author), Schneider, Guenter (Author), Sage, Julien (Author), Siveke, Jens T. (Author), Sanchez-Rivera, Francisco Javier (Contributor), Jacks, Tyler E. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-05-03T20:41:40Z.
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