Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing

Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing

Small cell lung carcinoma (SCLC) is a highly lethal, smoking-associated cancer with few known targetable genetic alterations. Using genome sequencing, we characterized the somatic evolution of a genetically engineered mouse model (GEMM) of SCLC initiated by loss of Trp53 and Rb1. We identified alter...

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Main Authors: Taylor-Weiner, Amaro (Author), Stewart, Chip (Author), Carter, Scott L (Author), Cibulskis, Kristian (Author), McKenna, Aaron (Author), Dooley, Alison (Author), Sougnez, Carrie (Author), Park, Jennifer (Author), Farago, Anna F (Author), Dayton, Talya (Author), Shefler, Erica (Author), Gabriel, Stacey (Author), Getz, Gad (Author), McFadden, David Glenn (Contributor), Papagiannakopoulos, Thales (Contributor), Bhutkar, Arjun (Contributor), Vernon, Amanda (Contributor), Malstrom, Scott E. (Contributor), Heimann, Megan Kristianne (Contributor), Parker, Jennifer E. (Contributor), Chen, Frances K. (Contributor), Jacks, Tyler E. (Contributor)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-07-05T18:08:36Z.
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