High-throughput mapping of regulatory DNA

High-throughput mapping of regulatory DNA

Quantifying the effects of cis-regulatory DNA on gene expression is a major challenge. Here, we present the multiplexed editing regulatory assay (MERA), a high-throughput CRISPR-Cas9-based approach that analyzes the functional impact of the regulatory genome in its native context. MERA tiles thousan...

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Bibliographic Details
Main Authors: Kooshesh, Kameron (Author), Banerjee, Budhaditya (Author), Emons, Bart J M (Author), Sherwood, Richard I (Author), Rajagopal, Nisha (Contributor), Srinivasan, Sharanya (Contributor), Guo, Yuchun (Contributor), Edwards, Matthew D (Contributor), Syed, Tahin Fahmid (Contributor), Gifford, David K (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-08-02T14:26:39Z.
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