Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System

In vitro hepatocyte culture systems have inherent limitations in capturing known human drug toxicities that arise from complex immune responses. Therefore, we established and characterized a liver immunocompetent coculture model and evaluated diclofenac (DCF) metabolic profiles, in vitro-in vivo cle...

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Bibliographic Details
Main Authors: Large, Emma (Author), Hughes, David J. (Author), Sarkar, Ujjal (Contributor), Ravindra, Kodihalli C. (Contributor), Young, Carissa L. (Contributor), Rivera-Burgos, Dinelia (Contributor), Yu, Jiajie (Contributor), Cirit, Murat (Contributor), Wishnok, John S (Contributor), Lauffenburger, Douglas A (Contributor), Griffith, Linda G (Contributor), Tannenbaum, Steven R (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Griffith, Linda (Contributor)
Format: Article
Language:English
Published: American Society for Pharmacology & Experimental Therapeutics (ASPET), 2017-08-18T15:46:07Z.
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