A Fungal-Selective Cytochrome bc₁ Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

A Fungal-Selective Cytochrome bc₁ Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

To cause disease, a microbial pathogen must adapt to the challenges of its host environment. The leading fungal pathogen Candida albicans colonizes nutrient-poor bodily niches, withstands attack from the immune system, and tolerates treatment with azole antifungals, often evolving resistance. To dis...

Full description

Bibliographic Details
Main Authors: Srinivas, Raja (Author), Lancaster, Alex K (Author), Scherz-Shouval, Ruth (Author), Whitesell, Luke (Author), Vincent, Benjamin Matteson (Contributor), Langlois, Jean-Baptiste (Contributor), Tidor, Bruce (Contributor), Buchwald, Stephen Leffler (Contributor), Lindquist, Susan (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-09-07T15:48:36Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items