Functional differences between PD-1⁺ and PD-1⁻CD4⁺ effector T cells in healthy donors and patients with glioblastoma multiforme

Functional differences between PD-1⁺ and PD-1⁻CD4⁺ effector T cells in healthy donors and patients with glioblastoma multiforme

mmune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) have been highly successful in the treatment of cancer. While PD-1 expression has been widely investigated, its role in CD4⁺ effector T cells in the setting of health and cancer remains unclear, particularly in the setting...

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Main Authors: Hernandez, Amanda L. (Author), Lowther, Daniel E. (Author), Lucca, Liliana E. (Author), Lerner, Benjamin A. (Author), Gunel, Murat (Author), Raddassi, Khadir (Author), Coric, Vlad (Author), Hafler, David A. (Author), Thomas, Brittany A. (Contributor), Love, John C (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Love, Christopher J. (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2017-10-02T18:23:29Z.
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