An engineered protein antagonist of K-Ras/B-Raf interaction

An engineered protein antagonist of K-Ras/B-Raf interaction

Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we report the engineering of a protein scaffold for preferent...

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Bibliographic Details
Main Authors: Parker, Jillian A. (Author), Kiefer, Jonathan D. (Author), Knihtila, Ryan (Author), McGee, John (Author), Verdine, Greg (Author), Mattos, Carla (Author), Kauke, Monique Jacqueline (Contributor), Traxlmayr, Michael (Contributor), Wittrup, Karl Dane (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-12-11T19:28:20Z.
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