3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the radical cofactor. Here, we present a 3.3-Å reso...

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Bibliographic Details
Main Authors: Brignole, Edward J (Contributor), Tsai, Kuang-Lei (Author), Chittuluru, Johnathan (Author), Li, Haoran (Author), Aye, Yimon (Author), Penczek, Pawel A (Author), Stubbe, JoAnne (Contributor), Drennan, Catherine L. (Contributor), Asturias, Francisco (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd, 2018-04-24T17:34:49Z.
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