Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathway, which promotes tumor cell growth. Despite the...

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Main Authors: Sayin, Volkan I (Author), LeBoeuf, Sarah E (Author), Singh, Simranjit X (Author), Biancur, Douglas (Author), Guzelhan, Betul S (Author), Alvarez, Samantha W (Author), Wu, Warren L (Author), Karakousi, Triantafyllia R (Author), Zavitsanou, Anastasia Maria (Author), Ubriaco, Julian (Author), Karagiannis, Dimitris (Author), Morris, Patrick J (Author), Thomas, Craig J (Author), Possemato, Richard (Author), Papagiannakopoulos, Thales (Author), Davidson, Shawn M (Contributor), Muir, Alexander (Contributor), Vander Heiden, Matthew G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd, 2018-04-24T18:55:54Z.
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