Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

Eliciting antibodies that are cross reactive with surface proteins of diverse strains of highly mutable pathogens (e.g., HIV, influenza) could be key for developing effective universal vaccines. Mutations in the framework regions of such broadly neutralizing antibodies (bnAbs) have been reported to...

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Bibliographic Details
Main Authors: Karplus, Martin (Author), Ovchinnikov, Victor A (Contributor), Louveau, Joy E (Contributor), Barton, John P (Contributor), Chakraborty, Arup K (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd, 2018-05-01T19:16:53Z.
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