Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold Interactions

Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold Interactions

Quantifying protein location and concentration is critical for understanding function in situ. Scaffold conjugated to environment-sensitive fluorophore (SuCESsFul) biosensors, in which a reporting fluorophore is conjugated to a binding scaffold, can, in principle, detect analytes of interest with hi...

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Main Authors: Dickson, Paige M. (Author), Marques, Bryan S. (Author), Zhao, Sixing (Author), Kiefer, Jonathan D. (Author), Wand, A. Joshua (Author), Griffith, Linda G. (Author), De Picciotto, Seymour (Contributor), Traxlmayr, Michael (Contributor), Socher, Elke Ricarda (Contributor), Cheung, Stephanie (Contributor), Imperiali, Barbara (Contributor), Wittrup, Karl Dane (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-06-22T16:07:27Z.
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