A Raf-competitive K-Ras binder can fail to functionally antagonize signaling
Mutated in approximately 30% of human cancers, Ras GTPases are the most common drivers of oncogenesis and render tumors unresponsive to many standard therapies. Despite decades of research, no drugs directly targeting Ras are currently available. We have previously characterized a small protein anta...
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Bibliographic Details
| Main Authors: |
Kauke, Monique Jacqueline
(Contributor),
Tisdale, Alison W.
(Contributor),
Kelly, Ryan Lewis
(Contributor),
Hemann, Michael
(Contributor),
Wittrup, Karl Dane
(Contributor),
Braun, Christian Joerg
(Author) |
|---|
| Other Authors: |
Massachusetts Institute of Technology. Department of Biological Engineering
(Contributor),
Massachusetts Institute of Technology. Department of Biology
(Contributor),
Massachusetts Institute of Technology. Department of Chemical Engineering
(Contributor),
Koch Institute for Integrative Cancer Research at MIT
(Contributor),
Braun, Christian Jorg
(Contributor) |
|---|
| Format: | Article
|
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| Language: | English |
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| Published: |
2018-06-25T13:50:15Z.
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| Subjects: | |
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| Online Access: | Get fulltext
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