Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

Tumor genetics guides patient selection for many new therapies, and cell culture studies have demonstrated that specific mutations can promote metabolic phenotypes. However, whether tissue context defines cancer dependence on specific metabolic pathways is unknown. Kras activation and Trp53 deletion...

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Main Authors: Ji, B. W. (Author), Dixit, P. D. (Author), Wolpin, B. M. (Author), Vitkup, D. (Author), Mayers, Jared R. (Contributor), Torrence, Margaret E. (Contributor), Danai, Laura V. (Contributor), Papagiannakopoulos, Thales (Contributor), Davidson, Shawn M. (Contributor), Bauer, Matthew R. (Contributor), Lau, Allison N. (Contributor), Hosios, Aaron Marc (Contributor), Muir, Alexander (Contributor), Chin, Christopher R. (Contributor), Freinkman, Elizaveta (Contributor), Jacks, Tyler E. (Contributor), Vander Heiden, Matthew G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2018-06-25T15:28:29Z.
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