Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium Tuberculosis Proteasome
The 20S core particle of the proteasome in Mycobacterium tuberculosis (Mtb) is a promising, yet unconventional, drug target. This multimeric peptidase is not essential, yet degrades proteins that have become damaged and toxic via reactions with nitric oxide (and/or the associated reactive nitrogen i...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS),
2018-07-09T14:26:32Z.
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| Subjects: | |
| Online Access: | Get fulltext |