Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium Tuberculosis Proteasome
The 20S core particle of the proteasome in Mycobacterium tuberculosis (Mtb) is a promising, yet unconventional, drug target. This multimeric peptidase is not essential, yet degrades proteins that have become damaged and toxic via reactions with nitric oxide (and/or the associated reactive nitrogen i...
Main Authors: | Totaro, Kyle A. (Author), Barthelme, Dominik (Contributor), Simpson, Peter T. (Author), Jiang, Xiuju (Author), Lin, Gang (Author), Nathan, Carl F. (Author), Sauer, Robert T. (Contributor), Sello, Jason K. (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS),
2018-07-09T14:26:32Z.
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Subjects: | |
Online Access: | Get fulltext |
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