Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism

Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the 2.8 Mb TAD where MYC resides. We find that these diverse cancer-specific super-enhancers, differin...

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Bibliographic Details
Main Authors: Schuijers, Jurian (Author), Day, Daniel Sindt (Author), Hnisz, Denes (Author), Lee, Tong Ihn (Author), Manteiga, John Colonnese (Contributor), Weintraub, Abraham Selby (Contributor), Zamudio Montes de Oca, Alicia (Contributor), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-23T16:50:12Z.
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