Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Traditional in vitro human liver cell culture models lose key hepatic functions such as metabolic activity during short-term culture. Advanced three-dimensional (3D) liver coculture platforms offer the potential for extended hepatocyte functionality and allow for the study of more complex biologic i...

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Bibliographic Details
Main Authors: Cosgrove, P. A. (Author), Dunn, R. T. (Author), Stolz, D. B. (Author), Hamadeh, H. (Author), Afshari, C. (Author), McBride, H. (Author), Long, Thomas J (Contributor), Griffith, Linda G (Contributor)
Other Authors: Massachusetts Institute of Technology. Biotechnology Process Engineering Center (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: American Society for Pharmacology & Experimental Therapeutics (ASPET), 2018-09-04T13:40:43Z.
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