Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

Transcription factor programming of pluripotent stem cells (PSCs) has emerged as an approach to generate human neurons for disease modeling. However, programming schemes produce a variety of cell types, and those neurons that are made often retain an immature phenotype, which limits their utility in...

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Main Authors: Nehme, Ralda (Author), Zuccaro, Emanuela (Author), Ghosh, Sulagna Dia (Author), Li, Chenchen (Author), Sherwood, John L. (Author), Pietilainen, Olli (Author), Barrett, Lindy E. (Author), Limone, Francesco (Author), Worringer, Kathleen A. (Author), Kommineni, Sravya (Author), Zang, Ying (Author), Cacchiarelli, Davide (Author), Meissner, Alex (Author), Adolfsson, Rolf (Author), Haggarty, Stephen (Author), Madison, Jon (Author), Muller, Matthias (Author), Arlotta, Paola (Author), Fu, Zhanyan (Author), Feng, Guoping (Contributor), Eggan, Kevin (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-09-07T17:23:53Z.
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