Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma

Glioblastoma (GBM) is a devastating malignancy with few therapeutic options. We identify PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition potently suppresses in vivo GBM tumors, including patient-derived xenografts. Pathway analysis implicates splicing in cellular PRM...

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Main Authors: Braun, Christian J. (Author), Stanciu, Monica (Contributor), Boutz, Paul L. (Author), Patterson, Jesse C. (Author), Calligaris, David (Author), Higuchi, Fumi (Author), Neupane, Rachit (Contributor), Fenoglio, Silvia (Contributor), Cahill, Daniel P. (Author), Wakimoto, Hiroaki (Author), Agar, Nathalie Y.R (Author), Yaffe, Michael B. (Author), Sharp, Phillip A. (Author), Hemann, Michael T. (Author), Lees, Jacqueline A. (Author), Boutz, Paul (Contributor), Patterson, Jesse C (Contributor), Yaffe, Michael B (Contributor), Hemann, Michael (Contributor), Lees, Jacqueline (Contributor), Braun, Christian Joerg (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Braun, Christian Jorg (Contributor), Sharp, Phillip A (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-10-31T19:11:29Z.
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