Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection

Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection

Sustained viremia after acute HIV infection is associated with profound CD4⁺ T cell loss and exhaustion of HIV-specific CD8⁺ T cell responses. To determine the impact of combination antiretroviral therapy (cART) on these processes, we examined the evolution of immune responses in acutely infected in...

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Main Authors: Ndhlovu, Zaza M. (Author), Kazer, Samuel Weisgurt (Author), Nkosi, Thandeka (Author), Ogunshola, Funsho (Author), Muema, Daniel M. (Author), Anmole, Gursev (Author), Swann, Shayda A. (Author), Moodley, Amber (Author), Dong, Krista (Author), Reddy, Tarylee (Author), Brockman, Mark A. (Author), Shalek, Alexander K (Author), Ndung'u, Thumbi (Author), Walker, Bruce (Author)
Other Authors: Ragon Institute of MGH, MIT and Harvard (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Broad Institute of MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science, 2020-01-23T20:46:26Z.
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