Integrated Mimicry of B Cell Antibody Mutagenesis Using Yeast Homologous Recombination
Antibody affinity maturation proceeds in vivo via a combination of point mutations, insertions, deletions, and combinatorial shuffling of light chains or portions of the heavy chain, thereby reducing the probability of trapping in local affinity optima in sequence space. In vivo homologous recombina...
| Main Authors: | , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature America, Inc,
2020-06-17T15:19:40Z.
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| Subjects: | |
| Online Access: | Get fulltext |