Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

The transcription factor Max is a basic-helix-loop-helix leucine zipper (bHLHLZ) protein that forms homodimers or interacts with other bHLHLZ proteins, including Myc and Mxd proteins. Among this dynamic network of interactions, the Myc/Max heterodimer has crucial roles in regulating normal cellular...

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Main Authors: Struntz, Nicholas B. (Author), Chen, Andrew I (Author), Deutzmann, Anja (Author), Wilson, Robert M. (Author), Stefan, Eric (Author), Evans, Helen L (Author), Ramirez, Maricela A. (Author), Liang, Tong (Author), Caballero, Francisco (Author), Wildschut, Mattheus H.E (Author), Neel, Dylan V (Author), Freeman, David B. (Author), Pop, Marius S (Author), McConkey, Marie (Author), Muller, Sandrine (Author), Curtin, Brice Harrison (Author), Tseng, Hanna (Author), Frombach, Kristen R. (Author), Butty, Vincent L G (Author), Levine, Stuart S. (Author), Feau, Clementine (Author), Elmiligy, Sarah (Author), Hong, Jiyoung A. (Author), Lewis, Timothy A. (Author), Vetere, Amedeo (Author), Clemons, Paul A. (Author), Malstrom, Scott E. (Author), Ebert, Benjamin L. (Author), Lin, Charles Y. (Author), Felsher, Dean W. (Author), Koehler, Angela Nicole (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-06-17T18:32:55Z.
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