BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells

BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells

The CCCTC-binding factor (CTCF), which anchors DNA loops that organize the genome into structural domains, has a central role in gene control by facilitating or constraining interactions between genes and their regulatory elements1,2. In cancer cells, the disruption of CTCF binding at specific loci...

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Main Authors: Debruyne, David N. (Author), Dries, Ruben (Author), Sengupta, Satyaki (Author), Seruggia, Davide (Author), Gao, Yang (Author), Sharma, Bandana (Author), Huang, Hao (Author), Moreau, Lisa (Author), McLane, Michael (Author), Day, Daniel Sindt (Author), Marco, Eugenio (Author), Chen, Ting (Author), Gray, Nathanael S. (Author), Wong, Kwok-Kin (Author), Orkin, Stuart H. (Author), Yuan, Guo-Cheng (Author), Young, Richard A. (Author), George, Rani E. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-08-06T21:27:10Z.
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