Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

A decline in stem cell function impairs tissue regeneration during ageing, but the role of the stem-cell-supporting niche in ageing is not well understood. The small intestine is maintained by actively cycling intestinal stem cells that are regulated by the Paneth cell niche1,2. Here we show that th...

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Main Authors: Pentinmikko, Nalle (Author), Iqbal, Sharif (Author), Mana, Miyeko (Author), Andersson, Simon (Author), Cognetta, Armand B. (Author), Suciu, Radu M. (Author), Roper, Jatin (Author), Luopajärvi, Kalle (Author), Markelin, Eino (Author), Gopalakrishnan, Swetha (Author), Smolander, Olli-Pekka (Author), Naranjo, Santiago (Author), Saarinen, Tuure (Author), Juuti, Anne (Author), Pietiläinen, Kirsi (Author), Auvinen, Petri (Author), Ristimäki, Ari (Author), Gupta, Nitin (Author), Tammela, Tuomas (Author), Jacks, Tyler E (Author), Sabatini, David (Author), Cravatt, Benjamin F. (Author), Yilmaz, Ömer H. (Author), Katajisto, Pekka (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-08-06T21:27:44Z.
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