Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β
Traditional fragment-based drug discovery (FBDD) relies heavily on structural analysis of the hits bound to their targets. Herein, we present a complementary approach based on diversity-oriented synthesis (DOS). A DOS-based fragment collection was able to produce initial hit compounds against the ta...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS),
2020-08-12T11:54:59Z.
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| Subjects: | |
| Online Access: | Get fulltext |