Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge. However, conditions for nAb-mediated protection after vaccination have not been established. Here, we selected groups of 6...

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Main Authors: Pauthner, Matthias G. (Author), Nkolola, Joseph P. (Author), Havenar-Daughton, Colin (Author), Murrell, Ben (Author), Reiss, Samantha M. (Author), Bastidas, Raiza (Author), Prévost, Jérémie (Author), Nedellec, Rebecca (Author), Bredow, Benjamin von (Author), Abbink, Peter (Author), Cottrell, Christopher A. (Author), Kulp, Daniel W. K (Author), Tokatlian, Talar (Author), Nogal, Bartek (Author), Bianchi, Matteo (Author), Li, Hui (Author), Lee, Jeong Hyun (Author), Butera, Salvatore T. (Author), Evans, David T. (Author), Hangartner, Lars (Author), Finzi, Andrés (Author), Wilson, Ian A. (Author), Wyatt, Richard T. (Author), Irvine, Darrell J. (Author), Irvine, Darrell J (Author), Schief, William R. (Author), Ward, Andrew B. (Author), Sanders, Rogier W. (Author), Crotty, Shane (Author), Shaw, George M. (Author), Barouch, Dan H. (Author), Burton, Dennis R. (Author)
Other Authors: Ragon Institute of MGH, MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-08-26T14:59:18Z.
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