Genome-scale screens identify factors regulating tumor cell responses to natural killer cells

Genome-scale screens identify factors regulating tumor cell responses to natural killer cells

To systematically define molecular features in human tumor cells that determine their degree of sensitivity to human allogeneic natural killer (NK) cells, we quantified the NK cell responsiveness of hundreds of molecularly annotated 'DNA-barcoded' solid tumor cell lines in multiplexed form...

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Main Authors: Sheffer, Michal (Author), Lowry, Emily (Author), Beelen, Nicky (Author), Borah, Minasri (Author), Amara, Suha Naffar-Abu (Author), Mader, Chris C. (Author), Roth, Jennifer A. (Author), Tsherniak, Aviad (Author), Freeman, Samuel S. (Author), Dashevsky, Olga (Author), Gandolfi, Sara (Author), Bender, Samantha (Author), Bryan, Jordan G. (Author), Zhu, Cong (Author), Wang, Li (Author), Tariq, Ifrah (Author), Kamath, Govinda M. (Author), Simoes, Ricardo De Matos (Author), Dhimolea, Eugen (Author), Yu, Channing (Author), Hu, Yiguo (Author), Dufva, Olli (Author), Giannakis, Marios (Author), Syrgkanis, Vasilis (Author), Fraenkel, Ernest (Author), Golub, Todd (Author), Romee, Rizwan (Author), Mustjoki, Satu (Author), Culhane, Aedin C. (Author), Wieten, Lotte (Author), Mitsiades, Constantine S. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2021-09-16T13:44:09Z.
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