IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production

IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production

Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of which is conferred by shared alleles. For decades, the Human Leukocyte Antigen (HLA) complex was the only known susceptibility locus for both T1D and MS, but loci outside...

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Main Authors: Maier, Lisa M. (Contributor), Lowe, Christopher E. (Author), Cooper, Jason (Author), Downes, Kate (Author), Anderson, David E. (Author), Severson, Christopher (Author), Clark, Pamela M. (Author), Healy, Brian (Author), Walker, Neil (Author), Aubin, Cristin (Contributor), Oksenberg, Jorge R. (Author), Hauser, Stephen L. (Author), Compston, Alastair (Author), Sawcer, Stephen (Author), De Jager, Philip L. (Contributor), Wicker, Linda S. (Author), Todd, John A. (Author), Hafler, David A. (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Harvard University- (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2010-03-15T12:42:45Z.
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