Direct cell reprogramming is a stochastic process amenable to acceleration

Direct cell reprogramming is a stochastic process amenable to acceleration

Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) can be achieved by overexpression of Oct4, Sox2, Klf4 and c-Myc transcription factors, but only a minority of donor somatic cells can be reprogrammed to pluripotency. Here we demonstrate that reprogramming is a continu...

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Bibliographic Details
Main Authors: Jaenisch, Rudolf (Contributor), Lengner, Christopher J. (Contributor), van Oudenaarden, Alexander (Contributor), Van Zon, Jeroen Sebastiaan (Contributor), Pando, Bernardo Fabian (Contributor), Saha, Krishanu (Author), Hanna, Jacob (Author), Creyghton, Menno P. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2010-09-07T19:56:43Z.
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