The Molecular Origin and Consequences of Escape from miRNA Regulation by HLA-C Alleles

The Molecular Origin and Consequences of Escape from miRNA Regulation by HLA-C Alleles

Differential expression of human leukocyte antigen C (HLA-C) allotypes is mediated by the binding of a microRNA, miR-148a, to the 3' untranslated region of some, but not all, HLA-C alleles. The binding results in lower levels of HLA-C expression, which is associated with higher levels of HIV-1...

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Main Authors: O'hUigin, Colm (Author), Kulkarni, Smita (Contributor), Xu, Yunping (Author), Deng, Zhihui (Author), Kidd, Judith (Author), Kidd, Kenneth (Author), Gao, Xiaojiang (Contributor), Carrington, Mary (Contributor)
Other Authors: Ragon Institute of MGH, MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2011-11-01T13:24:59Z.
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