Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

Due to its common dysregulation in epithelial-based cancers and extensive characterization of its role in tumor growth, epidermal growth factor receptor (EGFR) is a highly validated target for anticancer therapies. There has been particular interest in the development of monoclonal antibodies (mAbs)...

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Bibliographic Details
Main Authors: Spangler, Jamie Berta (Contributor), Neil, Jason Robert (Contributor), Abramovitch, Sivan (Author), Yarden, Yosef (Author), White, Forest M. (Contributor), Lauffenburger, Douglas A. (Author), Wittrup, Karl Dane (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2011-11-01T18:14:22Z.
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