Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to inadequacy of current preclinical screening assays, but recently established rodent models utilizing bacterial LPS co-administration to induce an inflammatory background have successfully reproduced idiosyncratic...

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Main Authors: Xu, Jinghai J. (Author), Hendriks, Bart S. (Author), Cosgrove, Benjamin D. (Contributor), King, Bracken Matheny (Contributor), Hasan, Maya A. (Contributor), Alexopoulos, Leonidas G. (Contributor), Farazi, Paraskevi A. (Contributor), Sorger, Peter K. (Contributor), Tidor, Bruce (Contributor), Griffith, Linda G. (Contributor), Lauffenburger, Douglas A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Biotechnology Process Engineering Center (Contributor), Massachusetts Institute of Technology. Cell Decision Process Center (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Elsevier Ltd., 2011-11-16T23:05:43Z.
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