The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF

The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF

The Caenorhabditis elegans class A and B synthetic multivulva (synMuv) genes redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. We identify a class A synMuv mutation in the promoter of the lin-3 EGF gene, establishing that lin-3 is the key biological target of the class A...

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Main Authors: Saffer, Adam M. (Contributor), Kim, Dong hyun (Contributor), van Oudenaarden, Alexander (Contributor), Horvitz, Howard Robert (Contributor)
Other Authors: move to dc.description.sponsorship (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Horvitz, H. Robert (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2012-02-23T17:57:09Z.
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