Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer

Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer

Human cancer cells frequently have regions of their DNA hypermethylated, which results in transcriptional silencing of affected genes and promotion of tumor formation. However, it is still unknown whether cancer-associated aberrant DNA methylation is targeted to specific genomic regions, whether thi...

Full description

Bibliographic Details
Main Authors: Steine, Eveline J. (Contributor), Ehrich, Mathias (Author), Bell, George W. (Contributor), Raj, Arjun (Contributor), Reddy, Seshamma (Contributor), van Oudenaarden, Alexander (Contributor), Jaenisch, Rudolf (Contributor), Linhart, Heinz G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Society for Clinical Investigation, 2012-09-28T16:18:49Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items