Genetic engineering of human ES and iPS cells using TALE nucleases

Genetic engineering of human ES and iPS cells using TALE nucleases

Targeted genetic engineering of human pluripotent cells is a prerequisite for exploiting their full potential. Such genetic manipulations can be achieved using site-specific nucleases. Here we engineered transcription activator-like effector nucleases (TALENs) for five distinct genomic loci. At all...

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Bibliographic Details
Main Authors: Hockemeyer, Dirk (Author), Wang, Haoyi (Author), Kiani, Samira (Author), Lai, Christine S. (Contributor), Gao, Qing (Author), Cassady, John P. (Contributor), Cost, Gregory J. (Author), Santiago, Yolanda (Author), Miller, Jeffrey C. (Author), Zeitler, Bryan (Author), Cherone, Jennifer Michelle (Author), Meng, Xiangdong (Author), Hinkley, Sarah J. (Author), Rebar, Edward J. (Author), Gregory, Philip D. (Author), Urnov, Fyodor D. (Author), Jaenisch, Rudolf (Contributor), Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014 (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2012-10-02T15:45:29Z.
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