Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer

Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new and interesting cancer targets, and recent studies h...

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Main Authors: Possemato, Richard (Contributor), Marks, Kevin M. (Author), Kim, Dohoon (Contributor), Birsoy, Kivanc (Contributor), Sethumadhavan, Shalini (Author), Woo, Hin-Koon (Author), Jang, Hyun G. (Author), Jha, Abhishek K. (Author), Chen, Walter W. (Contributor), Barrett, Francesca G. (Author), Stransky, Nicolas (Author), Tsun, Zhi-Yang (Contributor), Cowley, Glenn S. (Author), Barretina, Jordi (Author), Kalaany, Nada Y. (Contributor), Hsu, Peggy P. (Contributor), Ottina, Kathleen (Contributor), Chan, Albert M. (Contributor), Yuan, Bingbing B. (Contributor), Garraway, Levi A. (Author), Root, David E. (Author), Mino-Kenudson, Mari (Author), Brachtel, Elena F. (Author), Driggers, Edward M. (Author), Shaul, Yoav (Author), Pacold, Michael Edward (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Shaul, Yoav D. (Contributor), Pacold, Michael E. (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2012-11-01T18:41:15Z.
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