The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma

The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma

The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity in the mitogen-activated protein kinase pathway[subscript 1, 2]. BRAF(V600E) mutations are also present in benign melanocytic naevi3, highlighting the importance of addit...

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Main Authors: Ceol, Craig J. (Author), Houvras, Yariv (Author), Jane-Valbuena, Judit (Author), Bilodeau, Steve (Author), Orlando, David A. (Author), Battisti, Valentine (Author), Fritsch, Lauriane (Author), Lin, William M. (Author), Hollmann, Travis J. (Author), Ferre, Fabrizio (Author), Bourque, Caitlin (Author), Burke, Christopher J. (Author), Turner, Laura (Author), Uong, Audrey (Author), Johnson, Laura A. (Author), Beroukhim, Rameen (Author), Mermel, Craig H. (Contributor), Loda, Massimo (Author), Ait- (Author), Garraway, Levi A. (Author), Young, Richard A. (Author), Zon, Leonard I. (Author)
Format: Article
Language:English
Published: Nature Publishing Group, 2012-12-07T17:56:33Z.
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