BCL-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response

BCL-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response

The Bcl-2 family encompasses a diverse set of apoptotic regulators that are dynamically activated in response to various cell-intrinsic and -extrinsic stimuli. An extensive variety of cell culture experiments have identified effects of growth factors, cytokines, and drugs on Bcl-2 family functions,...

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Main Authors: Gilbert, Luke Andrew (Contributor), Meacham, Corbin Elizabeth (Contributor), Jiang, Hai (Contributor), Hemann, Michael (Contributor), Pritchard, Justin R. (Author), Shingleton, Jennifer R. (Author), Lauffenburger, Douglas A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Pritchard, Justin Robert (Contributor), Ricks, Jennifer L. (Contributor), Lauffenburger, Douglas A. (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2013-01-08T21:53:58Z.
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