SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

SOX2 is a master regulator of both pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs); however, we currently lack a detailed understanding of how SOX2 controls these distinct stem cell populations. Here we show by genome-wide analysis that, while SOX2 bound to a d...

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Bibliographic Details
Main Authors: Lodato, Michael Anthony (Contributor), Ng, Christopher W. (Contributor), Wamstad, Joseph Alan (Contributor), Cheng, Albert W. (Contributor), Thai, Kevin Kinh (Contributor), Fraenkel, Ernest (Contributor), Jaenisch, Rudolf (Contributor), Boyer, Laurie (Contributor)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. School of Science (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2013-04-11T15:50:18Z.
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