The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to model lineage evolution of the bnAbs PGT121-134 and found a positive correlation...

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Main Authors: Sok, Devin (Author), Laserson, Uri (Contributor), Laserson, Jonathan (Author), Liu, Yi (Author), Vigneault, Francois (Author), Julien, Jean-Philippe (Author), Briney, Bryan (Author), Ramos, Alejandra (Author), Saye, Karen F. (Author), Le, Khoa (Author), Mahan, Alison E. (Author), Wang, Shenshen (Contributor), Kardar, Mehran (Contributor), Yaari, Gur (Author), Walker, Laura M. (Author), Simen, Birgitte B. (Author), St. John, Elizabeth P. (Author), Chan-H (Author), Swiderek, Kristine (Author), Kleinstein, Stephen H. (Author), Alter, Galit (Author), Seaman, Michael S. (Author), Koller, Daphne (Author), Wilson, Ian A. (Author), Burton, Dennis R. (Author), Poignard, Pascal (Author), Chakraborty, Arup K (Author), Church, George M (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Mathematics (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Chakraborty, Arup K. (Contributor), Church, George M. (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-01-10T19:16:56Z.
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