O[superscript 6]-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation

O[superscript 6]-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation

The O[superscript 6]-methylguanine (O[superscript 6]MeG) DNA lesion is well known for its mutagenic, carcinogenic, and cytotoxic properties, and understanding how a cell processes such damage is of critical importance for improving current cancer therapy. Here we use human cells differing only in th...

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Bibliographic Details
Main Authors: Noonan, Ericka M. (Contributor), Shah, Dharini (Contributor), Yaffe, Michael B (Author), Lauffenburger, Douglas A (Author), Samson, Leona D (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Yaffe, Michael B. (Contributor), Lauffenburger, Douglas A. (Contributor), Samson, Leona D. (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry, The, 2014-02-28T18:48:50Z.
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