Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer
The mTOR protein is a master regulator of cell growth and proliferation, and inhibitors of its kinase activity have the potential to become new class of anticancer drugs. Starting from quinoline 1, which was identified in a biochemical mTOR assay, we developed a tricyclic benzonaphthyridinone inhibi...
Main Authors: | , , , , , , , , , , |
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Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS),
2014-02-28T20:07:15Z.
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Subjects: | |
Online Access: | Get fulltext |