Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome sequence and copy number to measure the fraction of cancer cells harboring each somatic mutation. We identified driver...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Other Authors: | , |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2014-03-10T16:15:55Z.
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Subjects: | |
Online Access: | Get fulltext |