Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome sequence and copy number to measure the fraction of cancer cells harboring each somatic mutation. We identified driver...

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Main Authors: Landau, Dan A (Author), Carter, Scott L. (Author), Stojanov, Petar (Author), McKenna, Aaron (Author), Stevenson, Kristen (Author), Lawrence, Michael S. (Author), Sougnez, Carrie (Author), Stewart, Chip (Author), Sivachenko, Andrey (Author), Wang, Lili (Author), Wan, Youzhong (Author), Zhang, Wandi (Author), Shukla, Sachet A (Author), Vartanov, Alexander (Author), Fernandes, Stacey M. (Author), Saksena, Gordon (Author), Cibulskis, Kristian (Author), Tesar, Bethany (Author), Gabriel, Stacey B. (Author), Hacohen, Nir (Author), Meyerson, Matthew L. (Author), Neuberg, Donna S. (Author), Brown, Jennifer R. (Author), Getz, Gad (Author), Wu, Catherine J (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-03-10T16:15:55Z.
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