Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins

Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins

Chromatin immunoprecipitation (ChIP) is the gold-standard technique for localizing nuclear proteins in the genome. We used ChIP, in combination with deep sequencing (Seq), to study the genome-wide distribution of the Silent information regulator (Sir) complex in Saccharomyces cerevisiae. We analyzed...

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Bibliographic Details
Main Authors: Teytelman, Leonid (Contributor), Thurtle, Deborah M. (Author), Rine, Jasper (Author), van Oudenaarden, Alexander (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-08-29T17:27:50Z.
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