Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex 1 (mTORC1), the canonical target of rapamycin, but also inhibits mTOR complex...

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Main Authors: Lamming, Dudley W. (Contributor), Mihaylova, Maria M. (Contributor), Katajisto, Pekka (Contributor), Baar, Emma L. (Author), Yilmaz, Omer (Contributor), Hutchins, Amanda W. (Contributor), Gultekin, Yetis (Contributor), Gaither, Rachel P. (Contributor), Sabatini, David M. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Anatomical Society/John Wiley & Sons, Inc, 2014-09-09T18:34:31Z.
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