In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes

In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes

In adoptive cell therapy (ACT), autologous tumor-specific T-cells isolated from cancer patients are activated and expanded ex vivo, then infused back into the individual to eliminate metastatic tumors. A major limitation of this promising approach is the rapid loss of ACT T-cell effector function in...

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Bibliographic Details
Main Authors: Zheng, Yiran (Contributor), Stephan, Matthias T. (Contributor), Gai, S. Annie (Contributor), Abraham, Wuhbet (Contributor), Shearer, Adrianne (Contributor), Irvine, Darrell J (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-09-24T12:57:15Z.
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