Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells

Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells

Valency requirements for B cell activation upon antigen encounter are poorly understood. OB1 transnuclear B cells express an IgG1 B cell receptor (BCR) specific for ovalbumin (OVA), the epitope of which can be mimicked using short synthetic peptides to allow antigen-specific engagement of the BCR. B...

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Main Authors: Avalos, Ana M. (Author), Bilate, Angelina M. (Author), Witte, Martin D. (Author), Tai, Albert K. (Author), He, Jiang (Author), Frushicheva, Maria P. (Contributor), Thill, Peter Daniel (Contributor), Meyer-Wentrup, Friederike (Author), Theile, Christopher S. (Author), Chakraborty, Arup K. (Contributor), Zhuang, Xiaowei (Author), Ploegh, Hidde (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, 2014-09-25T17:10:49Z.
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