Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

Resting memory CD4[superscript +] T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as suberanilohydroxamic acid (SAHA), romidepsin, and panobinostat have been shown to induce HIV expression in these resting cells...

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Main Authors: Jones, Richard Bradley (Contributor), O'Connor, Rachel (Contributor), Mueller, Stefanie (Contributor), Foley, Maria Hottelet (Contributor), Karel, Dan (Contributor), Lichterfeld, Mathias (Author), Kovacs, Colin (Author), Ostrowski, Mario A. (Author), Trocha, Alicja (Contributor), Walker, Bruce D. (Contributor), Szeto, Gregory (Author), Irvine, Darrell J (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Szeto, Gregory Lee (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-10-15T20:36:18Z.
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